Development of Bioscaffold for Detection of Cell Metabolics
Student: Yang Tian
Degree: Ph.D., August 2024
Major Professor: Dr. Ryan Tian
Nanoscience & Engineering
Slow and difficult cancer diagnosis optically on biopsy samples are contrasted by worldwide more and more cancer patients.
TiO2-nanowire bioscaffold shows excellent bio-compatible and electrochemical (E-Chem) properties.
Ultrafast ion transport on the TiO2-nanowire affords a low-cost, sensitive, E-Chem cancer sensor newly on a bioscaffold
Several electrochemical methods are combined in this first-ever metabolomics-based, rapid, simple, reliable, reproducible, and sensitive cell detection.
- Synthesize TiO2 nanowires bioscaffold directly on the Ti metal plate
- Optimize the nanowire morphologies and synthesis
- Control the cell-culture
- Optimize the sensors’ set up
- Analyze the impedance data
- Develop the new metabolomic cancer-sensor concept based on the data
- The TiO2-nanowire bioscaffold is biocompatible with human cells including the normal and cancerous cells
- Electrochemical techniques e.g. impedance and ion-transport rate are rationally integrated into the cancer cell sensor
- Quantitatively distinguished the benign type and aggressive type of human cancer cells
TiO2 bioscaffold has high ionic conductivity due to the special lattice- and surface-structures
This cancer-sensor is highly biocompatible and sensitive, ideal for identifying whether the cancer is benign or aggressive type
Dope different transition metals into the nanowire lattice to boost the nanowire conductivity and in turn the sensors sensitivity
Invent a mini-reactor to quantify the cell metabolomics in-situ in high-throughput
Quantify cell-cell communication in real-time on the bioscaffold